Research

Jose Morcuende, MD ($40,000)
“Molecular Genetics of Adolescent Idiopathic Scoliosis.”

Presentations:
1. Morcuende, JA, Minhas, R, Dolan, LA, Stevens, J, Beck, J, Weinstein, SL, Sheffield, V. Melatonin-1A receptor allelic variants in families with Adolescent Idiopathic Scoliosis. Annual meeting of the Pediatric Orthopaedic Surgery of North America, Salt Lake City, Utah, May 2002.

2. Wilkins J, Oji G, Ferguson A, Weinstein SL, Sheffield V, Morcuende JA. Genetic dissection of the melatonin pathway in patients with adolescent idiopathic scoliosis. Annual Meeting Pediatric Orthopaedic Society of North America, St. Louis, MO, April 29-May 1, 2004.

3. Wilkins J, Oji G, Gomez P, Ferguson A, Weinstein SL, Sheffield V, Morcuende JA. Mutation analysis of hMEl-1B, GRP50, and ROR-alpha in patients with familial idiopathic scoliosis. Mid-America Orthopaedic Association, Amelia Island, FL, April 15, 2005.

Papers:
1. Morcuende JA, Raman, M, Stevens J, Dolan L, Wang K, Weinstein SL, Sheffield V. Allelic variants of human melatonin 1-A (hMel-1A) in patients with familial adolescent idiopathic scoliosis. Spine, 28(17):2025-2029, 2003.

2. Morcuende JA, Wilkins J, Ferguson A, Sheffield V. Evaluation of melatonin pathway genes in patients with familial idiopathic scoliosis. Am J Hum Genet, submitted.

Additional Grants:
Gene Mapping for Familial Adolescent Idiopathic Scoliosis (1/1/03-12/31/04)

Principal Investigator: Jose A. Morcuende, MD, PhD

Co-Principal Investigators: Val Sheffield, MD, Stuart L Weinstein, MD, Kai Wang, PhD

Funded by: Howard Hughes Medical Institute ($50,000/ 2 years)

Genetic Mapping of Familial Idiopathic Scoliosis (6/1/2006-6/30/2009)

Principal Investigator: Jose A. Morcuende, MD, PhD

Co-Principal Investigator: Val Sheffield, MD, PhD

Funded by: National Health Institute (NIAMS)- 1 K08 AR053301-01A1 ($361,456)